Mscs, A Heterogeneous Members Of Stromal Stem Cells

MSCs are a heterogeneous subgroup of stromal stem cells. According to International Society for Cellular Therapy (ISCT) in 2007, they have three unique features: 1. They are non-hematopoietic multi-potential cells with selfrenewality and can differentiate into different types of mesodermic, ectodermic and endodermic tissues, especially bone, fat and cartilage. 2. They are fibroblastic or spindle-shaped in culture media and adhere to the culture vessel. 3. CD73, CD90 and CD105 are expressed in more than 95% of MSCs, while CD34, CD45, CD11b, CD14, CD19, CD79a, HLA-DR, CD80 and CD81 are expressed in less than 2% of MSCs. Moreover, D7Fib, STRO-1 and SSEA can also be assessed in MSCs (table 1) (6). Table 1 MSCs surface markers (6) CD73 (†¦show more content†¦Table2 The roles of biological cytokines released by MSCs A potent mitogen that stimulates the migration, proliferation and differentiation of mesodermal cell. bFGF Anti-apoptotic factors A regulator of growth and energy metabolism in the pathogenesis and progression of many malignancies IGF An important protein produced by fibroblasts that mediates the development of cancers. HGF key regulator of Angiogenesis VEGF Controlling proliferation and functional activity of granulocytes and monocytes GM-CSF suppressing the proliferation of T cells iNOS Immunomodulatory cytokines Direct role in immune response against pathogens and infectious agents IDO Induction of EMTs during embryonic development, wound healing, fibrotic diseases and pathogenesis of cancers TGFb Proliferation of human adult T cells and inhibition of differentiation of leukemic cells LIF An external agent of immunosuppression that inhibits the proliferation of T cells and production of IL-2. PGE2 Inflammatory cytokines The crucial role in homing, mobilization, implantation and differentiation of precursor cell SDF Maturation and differentiation of leukocytes SCF Cell Proliferation, differentiation, activation and apoptosis TNFÃŽ ± It Is needed for organization and